Upon realizing Akira was dead, Shikishima decided to use the SOL satellite on his subject. After returning at the conclusion of Volume 4, Kaneda is reunited with Kei and joins Kaisuke and Joker—the former Clown leader—in planning an assault on the Great Tokyo Empire. After the Colonel uses SOL to attack the Empire's army, a mysterious event opens a rift in the sky dumping massive debris from Akira's second explosion...as well as Kaneda (who was thought to have died in volume 3). While the gang was arrested, Col. Shikishima took Tetsuo to a lab. He then dons a worn red cape, ripped from a Resistance flag during the latter half of the film, after breaking out from the hospital a second time. After a near collision with Takashi and being experimented by the Japanese military government, he rapidly develops powerful, psychic abilities. Meanwhile, Tetsuo's Aide stages an unsuccessful Empire assault on Miyako's temple. Eventually, Tetsuo begins to suffer from uncanny headaches that appear every time he gets a sudden burst of heightened power. Tetsuo kills Yamada and the commandos; he also eludes Colonel Shikishima's attempts to kill him by guiding SOL with a laser designator.

SN… Kei's attack awakens Tetsuo's full powers, triggering a psionic reaction similar to Akira's. Eventually after Kaneda's arrival, Tetsuo mutates into a monstrous mass that kills Kaori and almost kills the colonel and Kaneda. The Colonel himself tries to use a laser satellite called SOL to kill Tetsuo and Akira, but only succeeds in severing Tetsuo's arm. Kei—accepting the role of a medium controlled by Lady Miyako and the Espers—arrives to battle Tetsuo. Tetsuo Shima (manga), Tetsuo Shima (anime) Tetsuo's voice can be heard at the end of the film, saying "Jan Rabson (Streamline 1989), Joshua Seth (Pioneer 2001)Take your favorite fandoms with you and never miss a beat. That night, Tetsuo was attacked and tortured telepathically by the Esper children, who used models and toys to try and kill Tetsuo. One night, during a gang war with the Clowns gang, Tetsuo suffers an accident after almost hitting a young boy named Takashi. After rapidly healing from his wounds, Tetsuo inquires about Akira, and forces Doctor Onishi, a project scientist, to take him to the Espers' playroom. Kaneda is his lifelong best friend.

Tetsuo is a young man of below-average height, and is slightly underweight with a very low muscular body. They are held in a high-security military skyscraper in Neo-Tokyo, but Kei soon escapes after becoming possessed as a medium by another Esper, Kiyoko. Tetsuo goes on a power trip as his newfound abilities grow, eventually leading him to his own destruction. Makes you angry? Similar to many other characters, Tetsuo's hair and eyes are a very dark brown. Dans les locaux de l'armée, Tetsuo apprend l'existence d'Akira, un mutant si puissant qu'il est enfermé profondément sous la terre. On December 6, 1982 (1992 in the English version), a nuclear explosion destroys Tokyo and starts World War III. Meanwhile, an international team of scientists meets up on an American aircraft carrier to study the recent psychic events in Neo-Tokyo, forming Project Juvenile "A". When he gets there, he is given a highly concentrated amount of heroine that would kill a normal person. Before the credits, you can hear Tetsuo saying "In the manga, the story goes the same, until Tetsuo discovers his powers. After escaping the hospital, he is found by the Clowns, who happen to be his gang's rivals. Tetsuo's power greatly overtakes him, transforming his body drastically.He then used his new powers to kill security guards, and staff trying to keep him from the Baby Room. Vaguely aware of who he is, they take him back into Neo-Tokyo. Kaneda and Kei meet up with Colonel Shikishima, and part ways as friends. Following the rally, Tetsuo's power begins to contort his physical body, causing it to absorb surrounding objects; he later learns that his abuse of his powers have caused them to expand beyond the confines of his body, giving him the ability to transmute inert matter into flesh and integrate it into his physical form. This instead results in his pain suddenly leaving, and his hair standing. After a short battle, Tetsuo discovered he could also fly. Tetsuo becomes heavily dependent on government-issued pills to quell his headaches. Tetsuo flies into space and brings down FLOYD, causing it to crash down upon the aircraft carrier, killing the navy's fleet admiral and some of the scientists. Tetsuo’s fate is not elaborated upon by the end of the film. They unsuccessfully stole Kaneda's motorbike and are intercepted by Clowns members. WHAT ARE YOU GONNA DO NOW? He uses his growing powers to intimidate them into giving him drugs to stop his headache, but in a sudden burst of impatience and power, Tetsuo splits one of their heads open. Throughout the story, he reflects more openly on feeling bossed around by others, and begins exhibiting an inferiority complex. He was voiced by Nozomu Sasaki who later voiced Kagehisa Anotsu in 2019 remake Blade of the Immortal in the Japanese dubbed version, and Joshua Seth in the English dubbed version. Colonel Shikishima arrives with the powerful drugs needed to suppress Tetsuo's violent headaches, extending an offer to join the project. Tetsuo is voiced by Nozomu Sasaki in Japanese, Jan Rabson in the 1989 Streamline English dub, and Joshua Seth in the 2001 Pioneer English dub. His name is a homage to a character in the anime, Armored Trooper Votoms.

The Clowns are easily defeated, but Tetsuo is nearly invincible because of his powers. With the help of Kiyoko, Masaru, and a resurrected Takashi, Akira is able to cancel out Tetsuo's explosion with one of his own.

Tetsuo pulls the cryogenic chamber above-ground and drops it onto Lady Miyako's temple.

" I am Tetsuo. Tetsuo Shima (島鉄雄 Shima Tetsuo) was a member of a teenage biker gang and the deuteragonist of Akira. Tetsuo returns from his battle with Kei and faces Yamada's team, but absorbs their biological attacks and temporarily regains control of his powers. He then suffers a breakdown and is taken away. Tetsuo goes missing in the explosion, and Kaneda and Kei come across Akira outside of the base. Yamada learns that the city has been divided into two factions: the cult of Lady Miyako, which provides food and medicine for the destitute refugees; and the Great Tokyo Empire, a group of zealots led by Tetsuo with Akira as a figurehead, both worshiped as deities for performing "miracles".
Tetsuo goes on a violent rampage in search of methods to improve and better control his new powers.