Cytochem. Z. Red pulp also removes and recycles components of old, damaged and dead red blood cells.White pulp is associated with the lymphatic function of the spleen.
Am. Rev. Brown, E. J., Hosea, S. W., and Frank, M. M. (1983) The role of antibody and complement in the reticuloendothelial clearance of pneumococci from the bloodstream.
Dis. Chan, E. Y. and MacLennan, I. C. (1993) Only a small proportion of splenic Chaplin, D. D. and Fu, Y. (1990) Analyses of thrombocytopenia in idiopathic thrombocytopenic purpura-prone mice by platelet transfer experiments between (NZW x BXSB)F1 and normal mice. Immunol. 172, 383-386.Cyster, J. G. (1999) Chemokines and cell migration in secondary lymphoid organs. (1996) Antibodies to a conserved region of HLA class I molecules, capable of modulating CD8 T cell-mediated function, are present in pooled normal immunoglobulin for therapeutic use. Kraal, G. (1992) Cells in the marginal zone of the spleen. It is interesting to notice that neural reflex can also participate in the modulation of immune functions. It acts as a filter for blood as part of the immune system. Lancet Andersson, U., Bjork, L., Skansen-Saphir, U., and Andersson, J. The interaction between lipid-conjugated antigens, macrophages, and T lymphocytes. Rees, E. P., Dijkstra, C. D., and van Rooijen, N. (1987) The early postnatal development of the primary immune response in rat popliteal lymph node, stimulated with thymus-independent type-1 and type-2 antigens. The spleen is the largest secondary lymphoid organ in the body and, as such, hosts a wide range of immunologic functions alongside its roles in hematopoiesis and red blood cell clearance. The spleen filters the blood, removing and destroying bacteria and other infectious organisms in the bloodstream. Clin. Science 286, 2098 - 2102.Dailey, M. O., Coleman, C. N., and Fajardo, L. F. (1981) Splenic injury caused by therapeutic irradiation. Lancet Hsu, S. M., Cossman, J., and Jaffe, E. S. (1983) Lymphocyte subsets in normal human lymphoid tissues. Humphrey, J. H. and Grennan, D. (1981) Different macrophage populations distinguished by means of fluorescent polysaccharides. J. Immunol. J. Exp. Ann. Clin. Immunology Stuart, F. P., Fitch, F. W., and McKearn, T. J. Occasionally, the spleen becomes so large – massive splenomegaly – it pushes on nearby organs and blood vessels. Immunology Krzysiek, R., Lefevre, E. A., Zou, W., Foussat, A., Bernard, J., Portier, A., Galanaud, P., and Richard, Y. The immune system is composed of cells, tissues and organs that work together to keep infectious agents out of the body thus protecting against diseases and infections. Invest. Tew, J. G., Wu, J., Qin, D., Helm, S., Burton, G. F., and Szakal, A. K. (1997) Follicular dendritic cells and presentation of antigen and co-stimulatory signals to B cells. J. Immunol. Its close proximity to the stomach and shared blood flow hint that a role in digestion is possible yet remains unknown. Arch. Exp. Proc. Chadburn, A. Cohn, D. A. and Schiffman, G. (1987) Immunoregulatory role of the spleen in antibody responses to pneumococcal polysaccharide antigens. The spleen filters the blood, removing and destroying bacteria and other infectious organisms in the bloodstream. Immunol. Fries, L. F., Brickman, C. M., and Frank, M. M. (1983) Monocyte receptors for the Fe portion of IgG increase in number in autoimmune hemolytic anemia and other hemolytic states and are decreased by glucocorticoid therapy. J. Exp. J. Exp. J. Immunol. J. Immunol. A., and Davies, A. J. S. (1980) Peanut lectin binding properties of germinal centres of mouse lymphoid tissue. J. Immunol. J. A., and Weissman, I. L. (1982) Mouse lymph node germinal centers contain a selected subset of T cells: the helper phenotype.