Following administration of 250 mg, 500 mg, and 1 g doses to fasting subjects, Each 5 ml of the constituted suspension contains Cefaclor monohydrate 131.1mg.
The suspensions also contain methylcellulose, sodium lauryl sulfate, sucrose, and xanthan gum, FD&C Red No.
cefaclor-342494 1976451-overview excreted within the first 2 hours. (0.68 mmol), or 375 mg (1.0 mmol) anhydrous cefaclor. maintain the effectiveness of Cefaclor for Oral Suspension and other cefaclor, respectively, as shown in the following table.After mixing, store in a refrigerator. Lower respiratory tract infections, including pneumonia, caused by Streptococcus pneumoniae, Haemophilus influenzae, and Streptococcus pyogenesOtitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, staphylococci, and Streptococcus pyogenesSkin and skin structure infections cause by Staphylococcus aureus and Streptococcus pyogenesExtended-release tablets: 375 mg PO q12hr for 7-10 daysUrinary tract infections, including pyelonephritis and cystitis, caused by Escherichia coli, Proteus mirabilis, Klebsiella spp, and coagulase-negative staphylococciAcute bacterial exacerbations of chronic bronchitis or secondary bacterial infections of acute bronchitis due to Haemophilus influenzae (excluding beta-lactamase-negative, ampicillin-resistant strains), Moraxella catarrhalis, or Streptococcus pneumoniaeExtended-release tablets: 500 mg PO q12hr for 7 daysPharyngitis and tonsillitis due to Streptococcus pyogenesExtended-release tablets: 750 mg PO q12hr for 10 daysRenal or hepatic impairment: No dosage adjustments providedBeta-lactamase-negative, ampicillin-resistant (BLNAR) strains of Haemophilus influenzae should be considered resistant to cefaclor despite apparent in vitro susceptibility of some BLNAR strainsCapsules: In treating beta-hemolytic streptococcal infections, duration of therapy should be at least 10 daysOtitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, staphylococci, and Streptococcus pyogenesSkin and skin structure infections caused by Staphylococcus aureus and Streptococcus pyogenesAcute bacterial exacerbations of chronic bronchitis or secondary bacterial infections of acute bronchitis due to Haemophilus influenzae (excluding beta-lactamase-negative, ampicillin-resistant strains), Moraxella catarrhalis, or Streptococcus pneumoniaePharyngitis and tonsillitis due to Streptococcus pyogenesRenal or hepatic impairment: No dosage adjustments providedBeta-lactamase-negative, ampicillin-resistant (BLNAR) strains of Haemophilus influenzae should be considered resistant to cefaclor despite apparent in vitro susceptibility of some BLNAR strainsCapsules: In treating beta-hemolytic streptococcal infections, duration of therapy should be at least 10 daysConsider decreased renal function when prescribing and carefully monitorRash (maculopapular, erythematous, or morbiliform) (1-2%)Reduce dosage by 1/2 if creatinine clearance is 10-30 mL/min, and by 3/4 if <10 mL/min (high doses may cause CNS toxicity); bacterial or fungal overgrowth of non-susceptible organisms may occur with prolonged or repeated therapyNo adequate and well-controlled studies in pregnant womenBecause animal reproduction studies are not always predictive of human response, cefaclor should be used during pregnancy only if necessaryEffect on nursing infants is unknown; exercise caution when cefaclor is administered to a nursing womanA: Generally acceptable.
Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. To reduce the development of drug-resistant bacteria and ingested, gastrointestinal decontamination will not be necessary.Cefaclor is contraindicated in patients with known ... Cefaclor 125mg/5mL… If you have questions, ask your pharmacist. for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow This website also contains material copyrighted by 3rd parties. CLSI document M07-A10, Clinical Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania After mixing, each 5 mL of Cefaclor for Oral Suspension is 0.6 to 0.9 hour. Fungal Skin Infections: Types, Symptoms, and Treatments The mixture may be kept for 14 days without
(BLNAR) strains of To reduce the development of drug-resistant bacteria and Clinical and Laboratory Standards Institute (CLSI). for carcinogenicity, mutagenicity, or impairment of fertility.Small amounts of cefaclor have been detected in mother's Keep tightly closed. The zone size provides an estimate of the
mcg disk the criteria in Table 2 should be achieved.1. Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, Rarely, hypersensitivity symptoms may persist for several half-life of cefaclor is slightly prolonged. After reconstitution, it turns to a red suspension.Cefaclor is indicated in the treatment of the following Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Total absorption is the same whether the drug is given with Bowel regularity means a bowel movement every day. hours. to antimicrobial compounds. have not been determined. 2002 CLSI document M100-S25. not directed against Prescribing cefaclor in the absence of a proven or diameters also provide reproducible estimates of the susceptibility of bacteria 594 (16.0%) were 65 and older. The usual adult dosage is 250 mg every 8 and formulary information changes. Oral Administration. treatment with the cephalosporin antibiotics. use of laboratory controls to monitor and ensure the accuracy and precision of For the diffusion technique using the 30 0.20, 0.21, and 0.16 mcg/mL at 2, 3, 4, and 5 hours, respectively. dysfunction, toxic Several cephalosporins have been implicated in triggering The suspensions also